Cholesterol-lowering drug may also reduce risk of blood clots

Statin drugs, commonly used to lower high cholesterol blood levels, have been shown to possibly decrease the risk for
thrombotic complications of antiphospholipid syndrome (APS), a disease associated with blood clotting and recurrent fetal
loss. Research conducted on animal models, has shown success in using the drug fluvastatin to inhibit the factors causing
development of thrombosis.


"Statin drugs appear to decrease abnormalities that increase the risk of thrombosis associated with antiphospholipid
antibodies," states Dr. Robin L. Brey in an editorial commenting on a study (Fluvastatin inhibits up-regulation of tissue
factor expression by antiphospholipid antibodies on endothelial cells, D.E. Ferrara, et al.) published in the Journal of
Thrombosis and Haemostasis. The presence of antiphospholipid antibodies (aPL) is a main characteristic of APS.


Current treatments include the use of blood thinning drugs like warfarin, which does not dissolve blood clots, but can
prevent their formation and further growth, according to The Cleveland Clinic. However, this treatment is difficult for
patients to take because of the need for frequent blood monitoring, potential bleeding complications, and the cost and
inconvenience due to multiple drug interactions. The study, led by D.E. Ferrara and researchers from Morehouse School of
Medicine, Emory University School of Medicine and University of Milan, Italy, suggests that statins may replace warfarin, or
certainly provide an alternative therapy pending more study in human trials.


In addition, "statin drugs seem to decrease the risk of heart attack and stroke independent of their effect on cholesterol
lowering and are relatively free of serious side effects," said Brey. "However, clinical trials must be performed to see if
their protective effect in patients with aPL holds up."


The National Organization for Rare Disorders reports that APS is characterized by recurring blood clots in individuals before
the age of 45 and may also be associated with repeated spontaneous abortions for no apparent reason in young women.


Both the study and related commentary are published in the Journal of Thrombosis and Haemostasis. Media wishing to receive a
PDF of the article contact medicalnewsbos.blackwellpublishing.


For an abstract on the study by Ferrara et al visit: blackwell-synergy/links/doi/10.1111/j.1538-7836.2004.00896.x/abs/


Or


journalth/showPage.php?template=Sottocategorie&search=12867&masterPage=abstract.html.



About the Authors


Commentating author, Robin L. Brey, M.D., is Professor of Medicine in the Department of Neurology and Associate Director of
the General Clinical Research Center Program at the University of Texas Health Science Center at San Antonio. Dr. Brey can be
reached for questions and interviews at breyuthscsa. Corresponding author of the study by Ferrara et al is Professor S.
S. Pierangeli, pieransmsm.


About the Journal of Thrombosis and Haemostasis


Journal of Thrombosis and Haemostasis, the official journal of the International Society on Thrombosis and Haemostasis, is
advancing science related to the important medical problems of thrombosis, bleeding disorders and vascular biology through
the diffusion and exchange of information and ideas within the international research community. The Journal of Thrombosis
and Haemostasis is now available in print and online.


About Blackwell Publishing


Blackwell Publishing is the world's leading society publisher, partnering with more than 550 academic and professional
societies. Blackwell publishes over 750 journals and 600 text and reference books annually, across a wide range of academic,
medical, and professional subjects.


Contact: Sharon Agsalda

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